Plasmafabriek Sanquin

RheDQuin

For the prevention of antibodies being produced against the blood group Rhesus D

Description

For the prevention of antibodies being produced against the blood group Rhesus D

RheDQuin is a solution for injection which contains special blood proteins. Other descriptions are immunoglobulins or antibodies. The active constituent in RheDQuin is an antibody that is active against the blood group Rhesus D, a blood protein structure in the red blood cells.

Product information

The products RheDQuin 1,000 IU and RheDQuin 375 IU are temporarily unavailable.

In the Netherlands, there is a registered alternative, Rhophylac (ZI-nr: 14873729, RVG 27449), available for this group of patients. This an equivalent product. 
Rhophylac is supplied in a pre-filled syringe of 1,000 IU anti-D immunoglobulin. Because there is no risk of overdose, it is - in consultation with the Dutch National Institute for Public Health and Environmental Protection (the RIVM) - recommended that the whole syringe should be administered (2 ml, 1,000 IU anti-D immunoglobulin), even when 375 IU is indicated. As efficient use of medicines is essential, Sanquin Plasma Products tries to ensure the out-of-stock period is as short as possible. However, we expect the out-of-stock period to continue until at least March 2020. Within the context of the PSIE-programme, Rhophylac can be ordered from the RIVM. Outside of this programme, it can be ordered from the company Devrimed (tel: +31 (0) 518 400 980) or the wholesaler. Reimbursement via the RIVM, within the context of the PSIE programme, can be issued in the usual way.

  • When is RheDQuin used?

    RheDQuin is used to prevent antibodies being formed against the blood group Rhesus D. These antibodies only form in people who do not have this blood group themselves. This is referred to as Rhesus negative.

    Mixing Rhesus D-positive blood with the blood of a Rhesus D-negative person can occur during blood transfusions, transplants, pregnancy and the birth of a baby. When Rhesus-positive blood enters the bloodstream of a Rhesus-negative person, the body may recognise this as foreign and antibodies against Rhesus D can be formed.

    Rhesus D-antibodies such as RheDQuin remove the Rhesus D-positive blood cells from the bloodstream. This prevents the body’s natural immune response.

    Read more in the RheDQuin leaflet (pdf).

    How is RheDQuin used?
    RheDQuin is a solution to be injected deep into the muscle (intramuscular).

    The dosage
    The dosage of RheDQuin depends on the situation. The quantity of Rhesus D positive cells in the bloodstream determines the volume to be administered.

    Read more in the RheDQuin leaflet (pdf).

  • How is RheDQuin administered?

    RheDQuin is a solution to be injected deep into the muscle (intramuscular).

    The dosage
    The dosage of RheDQuin depends on the situation. The quantity of Rhesus D positive cells in the bloodstream determines the volume to be administered.

    How is RheDQuin administered?

    • The product should be suctioned into a sterile syringe.
    • Remove the needle from the syringe and replace this by an intramuscular needle.
    • Remove any air in the syringe, disinfect the skin and insert the needle into the muscle.
    • Check the needle is not in a blood vessel.
    • In one dose, administer a deep intramuscular injection.

    For more information, please read the RheDQuin leaflet (pdf).

  • What are the side effects of RheDQuin?

    RheDQuin can cause side effects, in the same way as all other medicines. Not everyone suffers from these side effects.

    The patient may feel some pain or sensitivity at the site of the injection. Very rarely, the patient could develop a fever and/or a skin rash. Mild or serious hypersensitivity reactions rarely occur.

  • How is RheDQuin stored?

    • out of reach and sight of children
    • between 2-8 °C (not to be frozen)
    • in the original packaging to protect it from the light


    Not to be used after the expiry date
    Do not use RheDQuin after its expiry date. This is stipulated on the label, on the vial and on the box.

    Disposal
    Do not dispose of the medicine via waste water or with household waste. Unused medicines can be handed over to a pharmacy. These measures help to protect the environment.

    Read more in the RheDQuin leaflet (pdf).