Plasmafabriek Sanquin

HepBQuin

HepBQuin is a medicine with a high titre of hepatitis B antibodies of at least 100 IU/ml

Description

HepBQuin is a medicine with a high titre of hepatitis B antibodies of at least 100 IU/ml

HepBQuin is a solution to be injected, and is administered as an intramuscular injection to prevent hepatitis B.

Product information

Currently, HepBQuin 150 IU is not available due to production problems.

As there is no replacement product in the Netherlands and it concerns a serious indication, Sanquin has ensured that, in consultation with the Inspectorate for Health and Youth Care (Inspectie voor de Gezondheidszorg en Jeugd, IGJ), that an equivalent alternative is available. This is Hepatitis B Immunoglobulin, ImmunoHBs 180IU/ml, from Kedrion with ZI number 16798082. This product will be reimbursed by the healthcare insurer.

The product from Kedrion is an equivalent product and is delivered in a vial of 180 IU per ml in stead of Sanquin’s HepBQuin 150 IU. For the prevention of vertical transmission, within the PSIE-programme (Pre-natal Screening Infectious diseases and Erythrocytes immunisation) 1 vial of 150 IU is recommended. In consultation with the National Institute for Public Health and Environmental Protection (RIVM), we recommend administering the entire 180 IU vial in the case of newborns. Hereby, there is no risk of an overdose. An English language leaflet is enclosed in the packaging.

The product HepBQuin 500 IU is available as usual.

  • When is HepBQuin used?

    HepBQuin is used to prevent a patient contracting hepatitis B.

    That is the case when:

    1. Someone is incidentally infected by the hepatitis B virus because:
      a. he/she has never been vaccinated against hepatitis B in the past;
      b. his/her vaccinations were incomplete;
      c. the level of antibodies against the hepatitis B virus in his/her blood were too low or unknown.
    2. Someone runs a continuous risk of being infected with the hepatitis virus because:
      a. he/she cannot be vaccinated;
      b. he/she had been vaccinated, but no hepatitis B antibodies have formed.
    3. New born babies of mothers who carry the hepatitis B virus.

      Read more in the HepBQuin leaflet (pdf).
  • How is HepBQuin used?

    HepBQuin is a solution for an injection.

    To prevent hepatitis B an intramuscular injection of HepBQuin can be administered.

  • What dosage of HepBQuin is administered?

    The physician treating the patient specifies the dosage of HepBQuin. The quantity of HepBQuin which is necessary depends on the reason for which it is being administered.

  • How is HepBQuin administered?

    • Remove the vial from the refrigerator and allow it to reach room temperature.
    • It is a clear solution.
    • During the period of storage, slight turbidity or a small amount of precipitation may occur. This will not affect the efficacy of the product.
    • Dependent on the dosage more than one vial may be used.
    • The content of several vials can be mixed for administration to the patient.
    • To administer a large dosage (more than 5 ml), it is recommended that the dosage be distributed over several injection sites.
    • The product should be suctioned into a sterile syringe.

    To prevent hepatitis B an intramuscular injection of HepBQuin can be administered.

    Read more in the HepBQuin leaflet (pdf).

  • What are the side effects of HepBQuin?

    HepBQuin can cause side effects, in the same way as all other medicines. The patient may feel some pain or sensitivity at the site of the injection.

    Very rarely, the patient could develop a fever and/or a skin rash. Side effects include nausea, vomiting, low blood pressure, a rapid heartbeat and hypersensitivity reactions.    

    Read more in the HepBQuin leaflet (pdf).

  • How is HepBQuin stored?

    • out of reach and sight of children
    • in the refrigerator at 2 - 8 °C (therefore, do not freeze)
    • in the original packaging to protect it from the light

    Storage recommendationsDo not use HepBQuin after its expiry date. This is stipulated on the label, on the vial and on the box.

    Disposal
    Do not dispose of the medicine via waste water or with household waste. Medicines which are no longer being used can be handed  over to a pharmacy. These measures help to protect the environment.

    Read more in the HepBQuin leaflet (pdf).