Plasmafabriek Sanquin


To supplement a deficiency of the coagulation factor VIII in patients with Haemophilia A


Aafact is a medicine that helps correct a coagulation deficiency.

Factor VIII is a constituent that is normally present in people’s blood and is a factor in the coagulation process. A lack of factor VIII disrupts coagulation. This can give rise to haemorrhages (bleeding). Aafact compensates for the deficiency and, in doing so, prevents or combats the bleeding.

Product information

  • For whom is Aafact prescribed?

    Aafact is used to prevent or treat bleeding in people who have Haemophilia A.

    There is little experience of treating women who have a factor VIII deficiency. No research has been conducted into the use of Aafact during pregnancy and breast feeding.

    Read more in the Aafact leaflet (pdf).

  • How is Aafact used?

    Aafact is injected intravenously into a blood vessel.

    What dosage of Aafact is prescribed?
    The physician treating the patient specifies the dosage of Aafact. The dosage and the frequency depend on:

    • the seriousness of the situation (bleeding/procedure);
    • the patient’s weight;
    • the level of the coagulation factor in the blood.

    How is Aafact dissolved?

    • The vial containing the powder is dissolved by adding water for injections to the vial. Do this at room temperature.
    • After a maximum of 10 minutes, the powder will have dissolved.
    • The resultant solution is clear.
    • Do not use any solution that is turbid or contains deposits.

    How do you administer Aafact?

    • The product should be suctioned into a sterile syringe.
    • Remove the needle from the syringe and replace this by an intravenous needle.
    • Remove any air in the syringe, disinfect the skin and insert the needle into the vein.
    • Administer the vial of Aafact as quickly as possible. At the latest, within three hours.

      Read more in the Aafact leaflet (pdf).
  • What are the side effects of Aafact?

    In theory, a patient may experience an allergic reaction (hypersensitivity). Mild hypersensitivity, such as hives (urticaria) can be treated. In the event of serious allergic reactions (anaphylactic shock), the administration of the medicine must be stopped immediately and other suitable treatment will be required.

    Antibodies against Aafact may develop. These antibodies are known as ‘inhibitors’. If such inhibitors occur, the clinical response to Aafact will not be as good. The blood should be checked regularly to ascertain whether these antibodies are present.

  • How should Aafact be stored?

    • Store Aafact out of reach and sight of children
    • Store it in the refrigerator at 2 - 8 °C (therefore, do not freeze)
    • Store it in the original packaging to protect it from the light
    • Store the vial of water for the injection out of the fridge (room temperature).

    Not to be used after the expiry date

    Do not use Aafact after its expiry date. This is stipulated on the label, on the vial and on the box.

    Read more in the Aafact leaflet (pdf).

    Hand into a pharmacy
    Hand any used medicines into a pharmacy. By not disposing of medicines via waste water or household waste, we are helping to protect the environment.

    Read more in the leaflet of Aafact (pdf).